PCNA

proliferating cell nuclear antigen

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

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Products

Proteins (19)

Type

Over-Expression Lysate (6)

Recombinant (12)

Target

PCNA (19)

Publications

No (18)

Yes (1)

Tag

6His, N-terminus (3)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His-GST (1)

His-GST-S (1)

Myc-DDK (Flag) (7)

Species

All species (1)

Human (13)

Saccharomyces cerevisiae (2)

Source

293T Cells (3)

Baculovirus (1)

E. coli (8)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (2)

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Human PCNA Protein (Recombinant) - LS-G3526

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PCNA Protein (Recombinant His) (Met1-Ser261) - LS-G97749

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

31 kDa

Price:

100 µg/$843

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Human PCNA Protein (Recombinant 6His, N-terminus) (Phe2-Leu262) - LS-G26336

(4.0) Rating

(1) Publication(s)

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

29 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127593

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

100 µg/$494

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PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104197

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

100 µg/$494

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PCNA Protein (Recombinant His-GST-S) (aa6-261) - LS-G24063

Source:

E. coli

Tag:

His-GST-S

Molecular Weight:

58.1 kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Human PCNA Protein (Recombinant GST) (Full Length) - LS-G29650

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.45 kDa

Price:

10 µg/$479; 25 µg/$670

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Saccharomyces cerevisiae PCNA Protein (Recombinant 6His, N-terminus) (aa1-258) - LS-G64395

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$679; 20 µg/$429; 1 mg/$1,973

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Saccharomyces cerevisiae PCNA Protein (Recombinant 6His-SUMO, N-terminus) (aa1-258) - LS-G64398

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human PCNA Protein (Recombinant 6His, N-terminus) (aa1-261) - LS-G56447

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$420; 20 µg/$323; 1 mg/$1,355

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Human PCNA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67862

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

20 µg/$1,107

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Human PCNA Protein (Recombinant GST, N-terminus) (aa152-261) - LS-G59525

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80862

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

20 µg/$150

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Human PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80863

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

20 µg/$150

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Human PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80864

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

20 µg/$150

Select

PCNA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.6 kDa

Price:

100 µg/$494

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Human PCNA Protein (Recombinant His) (aa1-261) - LS-G140966

Source:

E. coli

Sequence Length:

260 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

28.71 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human PCNA Protein - LS-G133976

Source:

E. coli

Tag:

None

Molecular Weight:

28.8 kDa

Price:

5 µg/$329; 25 µg/$412; 1000 µg/$3,417

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Human PCNA Protein (Recombinant His-GST) - LS-G12454

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.8 kDa

Price:

10 µg/$321; 50 µg/$552; 100 µg/$827

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