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PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
PCK1 is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
| Gene Name: | phosphoenolpyruvate carboxykinase 1 (soluble) |
| Synonyms: | PCK1, PEPCKC, Phosphopyruvate carboxylase, PEP carboxykinase, PEPCK-C, PEPCK1 |
| Target Sequences: | NM_002591 NP_002582.3 P35558 |
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