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PCGF6

polycomb group ring finger 6

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Name: polycomb group ring finger 6
Synonyms: PCGF6, MBLR, Polycomb group ring finger 6, RING finger protein 134, RNF134
Target Sequences: NM_032154 NP_115530.2 Q9BYE7

Publications (1)

1
PRC1 Catalytic Activity Is Central to Polycomb System Function. Neil P Blackledge, Nadezda A Fursova, Jessica R Kelley, Miles K Huseyin, Angelika Feldmann, Robert J Klose. Molecular cell. 2020 Feb;77:857-874e9. [Full Text Article] [PubMed:31883950] [PMC:PMC7033600]

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
PCGF6 (6)
No (6)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
PCGF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.9 kDa
100 µg/$494
PCGF6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PCGF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.9 kDa
20 µg/$150
PCGF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.1 kDa
20 µg/$150
PCGF6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30.1 kDa
100 µg/$494
PCGF6 Protein - 12.5% SDS-PAGE of human PCGF6 stained with Coomassie Blue
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Wheat Germ Extract
GST
56.8 kDa
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).