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PCGF6

polycomb group ring finger 6

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Name: polycomb group ring finger 6
Synonyms: PCGF6, MBLR, Polycomb group ring finger 6, RING finger protein 134, RNF134
Target Sequences: NM_032154 NP_115530.2 Q9BYE7

Publications (1)

1
PRC1 Catalytic Activity Is Central to Polycomb System Function. Neil P Blackledge, Nadezda A Fursova, Jessica R Kelley, Miles K Huseyin, Angelika Feldmann, Robert J Klose. Molecular cell. 2020 Feb;77:857-874e9. [Full Text Article] [PubMed:31883950] [PMC:PMC7033600]

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Products
Antibodies (20)
Primary (20)
PCGF6 (20)
Human (19)
Mouse (2)
Rat (1)
Monkey (3)
WB (17)
ELISA (10)
IF (2)
Peptide-ELISA (1)
rabbit (20)
IgG (13)
polyclonal pc (20)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (9)
aa190-217 (7)
aa179-228 (4)
aa215-249 (1)
aa261-295 (1)
No (20)
PCGF6 Antibody - PCGF6 Antibody western blot of NCI-H292,rat liver,stomach and testis cell line lysates (35 ug/lane). The PCGF6 antibody detected the PCGF6 protein (arrow).
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) Antibody
Human
WB
Unconjugated
400 µl/$393
PCGF6 Antibody - Immunofluorescence analysis of HeLa cells.
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PCGF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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PCGF6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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PCGF6 Rabbit anti-Human Polyclonal (aa190-217) (Azide-free) (HRP) Antibody
Human
WB
HRP Conjugated, Azide-free
200 µl/$952
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PCGF6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
PCGF6 Antibody - Western Blot Positive WB detected in: PC3 whole cell lysate, MCF-7 whole cell lysate All Lanes: PCGF6 antibody at 3.1µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 40, 31 KDa Observed band size: 40 KDa
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PCGF6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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PCGF6 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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PCGF6 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PCGF6 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
PCGF6 Antibody - Anti-PCGF6 Antibody at 1:2000 dilution + rat testis lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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PCGF6 Rabbit anti-Human Polyclonal (aa215-249) Antibody
Rat
Peptide-ELISA, WB
Unconjugated
400 µl/$393
PCGF6 Antibody - PCGF6 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PCGF6 Rabbit anti-Human Polyclonal (aa179-228) Antibody
Human
WB
Unconjugated
100 µl/$424
PCGF6 Antibody - PCGF6 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PCGF6 Rabbit anti-Human Polyclonal (aa179-228) (HRP) Antibody
Human, Monkey
WB
HRP Conjugated
100 µl/$469
PCGF6 Antibody - PCGF6 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PCGF6 Rabbit anti-Human Polyclonal (aa179-228) (Biotin) Antibody
Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PCGF6 Antibody - PCGF6 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PCGF6 Rabbit anti-Human Polyclonal (aa179-228) (FITC) Antibody
Human, Monkey
WB
FITC Conjugated
100 µl/$469
PCGF6 Antibody - Western blot of lysate from human kidney tissue with PCGF6 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20 ug.
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PCGF6 Rabbit anti-Human Polyclonal (aa261-295) Antibody
Human
WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).