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Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Gene Name: | polycomb group ring finger 6 |
Synonyms: | PCGF6, MBLR, Polycomb group ring finger 6, RING finger protein 134, RNF134 |
Target Sequences: | NM_032154 NP_115530.2 Q9BYE7 |
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