PCGF2 / MEL-18

polycomb group ring finger 2

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PCGF2 / MEL-18 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PCGF2 / MEL-18 Protein (Recombinant GST) (Full Length) - LS-G30978

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.58 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PCGF2 / MEL-18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75592

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$150

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Human PCGF2 / MEL-18 Protein (Recombinant GST, N-terminus) (aa236-294) - LS-G60577

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PCGF2 / MEL-18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100979

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

100 µg/$494

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