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PCDHGC3 / PCDH2
protocadherin gamma subfamily C, 3
PCDHGC3 / PCDH2 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
| Gene Name: | protocadherin gamma subfamily C, 3 |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | PCDHGC3, Cadherin-like 2, PCDH-GAMMA-C3, PC-43, PCDH2, Protocadherin 43, Protocadherin gamma-C3, Protocadherin-2, Protocadherin 2, PC43, Protocadherin-43 |
| Target Sequences: | NM_002588 NP_002579.2 Q9UN70 |
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