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PCDHGB4
Protocadherin Gamma Subfamily B, 4
PCDHGB4 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.
| Gene Name: | Protocadherin Gamma Subfamily B, 4 |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | PCDHGB4, Cadherin 20, Fibroblast cadherin-2, PCDH-GAMMA-B4, Protocadherin gamma-B4, Cadherin-20, Fib2, Fibroblast cadherin FIB2 |
| Target Sequences: | NM_003736 NP_003727.1 Q9UN71 |
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