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PCDHA10

protocadherin alpha 10

PCDHA10 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Gene Name: protocadherin alpha 10
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: PCDHA10, CNRN8, PCDH-ALPHA10, Protocadherin alpha-10, PCDH-alpha-10, CNR8, CNRS8, CRNR8, KIAA0345-like 4, Ortholog to mouse CNR8, Protocadherin alpha 10
Target Sequences: NM_018901 NP_061724.1 Q9Y5I2

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).