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PCA1 / ALKBH3

alkB, alkylation repair homolog 3 (E. coli)

Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.

Gene Name:	alkB, alkylation repair homolog 3 (E. coli)
Synonyms:	ALKBH3, ABH3, DEPC1, DEPC-1, Prostate cancer antigen 1, PCA1, Prostate cancer antigen-1
Target Sequences:	Q96Q83 Q96Q83

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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