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Lynnwood, WA 98036
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PC / Pyruvate Carboxylase
pyruvate carboxylase
PC / Pyruvate Carboxylase is pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
| Gene Name: | pyruvate carboxylase |
| Synonyms: | PC, PCB, Pyruvate carboxylase, Pyruvic carboxylase |
| Target Sequences: | NM_000920 NP_000911.2 P11498 |
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