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PBK / TOPK
PDZ binding kinase
TOPK is a TOPK protein kinase which may be associated with cell signaling in lymphokine-activated killer T (T-LAK) cells and spermatogenesis. Studies suggest that mitotic phosphorylation is required for its catalytic activity. Similar to MEK3/MAP2K3 and MKK6/MAP2K6, activated TOPK phosphorylates the MAP kinase p38. At least two mRNA variants have been identified - a major full-length form and a minor spliced form at the 5'-site, both encoding the same protein. TOPK has been shown to be upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.
| Gene Name: | PDZ binding kinase |
| Family/Subfamily: | Protein Kinase , TOPK |
| Synonyms: | PBK, CT84, MAPKK-like protein kinase, PDZ binding kinase, PDZ-binding kinase, Cancer/testis antigen 84, Nori-3, SPK, TOPK |
| Target Sequences: | NM_018492 NP_060962.2 Q96KB5 |
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