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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PAXIP1 / PTIP

PAX interacting (with transcription-activation domain) protein 1

Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.

Gene Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PAXIP1, CAGF29, CAGF28, PAX-interacting protein 1, TNRC2, PAXIP1L, PTIP, PACIP1
Target Sequences: NM_007349 NP_031375.3 Q6ZW49

Filtered By: None
Target
PAXIP1 / PTIP (12)
Reactivity
Human (12)
Mouse (4)
Rat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Pig (1)
Rabbit (4)
Xenopus (4)
Zebrafish (4)
Application
WB (8)
ELISA (5)
IF (1)
IP (2)
Host
rabbit (12)
Isotype
IgG (11)
Clonality
polyclonal pc (12)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (6)
Epitope
aa248-297 (4)
aa1-50 (1)
aa2-35 (1)
Publications
No (12)
Showing 1-12 of 12 results

PAXIP1 / PTIP Antibody LS-C754702
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
ELISA IF IP WB
Unconjugated
100µg  $335.00

PAXIP1 / PTIP Antibody (aa1-50) LS-C287267
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Pig, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

PAXIP1 / PTIP Antibody LS-C398831
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
ELISA
Unconjugated
50µg  $285.00; 100µg  $385.00

PAXIP1 / PTIP Antibody (HRP) LS-C398832
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

PAXIP1 / PTIP Antibody (Biotin) LS-C398834
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

PAXIP1 / PTIP Antibody (FITC) LS-C398833
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

PAXIP1 / PTIP Antibody LS-C410599
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Human
WB
Unconjugated
100µl  $295.00; 200µl  $385.00

PAXIP1 / PTIP Antibody (aa248-297) LS-C81652
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Xenopus, Chicken, Zebrafish, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
50µg  $365.00
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PAXIP1 / PTIP Antibody (aa248-297, HRP) LS-C454850
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PAXIP1 / PTIP Antibody (aa248-297, Biotin) LS-C454848
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PAXIP1 / PTIP Antibody (aa248-297, FITC) LS-C454849
Rabbit Polyclonal (IgG) to Human PAXIP1 / PTIP
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
WB
FITC Conjugated
100µl 1mg/ml  $385.00
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
721_B cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PAXIP1 / PTIP Antibody (aa2-35) LS-C344426
Rabbit Polyclonal to Human PAXIP1 / PTIP
Human
WB
Unconjugated
400µl  $305.00
Western blot of lysate from 293 cell line with PAXIP1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.
Western blot of lysate from 293 cell line with PAXIP1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35 ug.
Showing 1-12 of 12 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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