PARP13 / ZC3HAV1

zinc finger CCCH-type, antiviral 1

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

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Products

Antibodies (14)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (14)

Recombinant (2)

Target

PARP13 / ZC3HAV1 (18)

Reactivity

Human (14)

Mouse (2)

Rat (1)

Application

IHC (11)

IHC-P (1)

WB (13)

ELISA (10)

ICC (1)

IF (1)

IP (2)

Peptide-ELISA (1)

Host

rabbit (14)

Isotype

IgG (11)

Clonality

polyclonal pc (14)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (9)

Epitope

aa604-632 (7)

Publications

No (18)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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PARP13 / ZC3HAV1 Antibody LS-C410752

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PARP13 / ZC3HAV1 Antibody LS-C115869

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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PARP13 / ZC3HAV1 Antibody LS-C802836

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PARP13 / ZC3HAV1 Antibody (aa604-632) LS-C326461

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PARP13 / ZC3HAV1 Antibody (aa604-632, Biotin) LS-C242911

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PARP13 / ZC3HAV1 Antibody (aa604-632, FITC) LS-C242912

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PARP13 / ZC3HAV1 Antibody (aa604-632, Azide-free, HRP) LS-C247285

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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PARP13 / ZC3HAV1 Antibody (aa604-632, APC) LS-C242909

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PARP13 / ZC3HAV1 Antibody (aa604-632, PE) LS-C242913

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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PARP13 / ZC3HAV1 Antibody LS-C660700

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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PARP13 / ZC3HAV1 Antibody (aa604-632) LS-C160741

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal (aa604-632) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PARP13 / ZC3HAV1 Antibody LS-C831136

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

PARP13 / ZC3HAV1 Antibody LS-C778761

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PARP13 / ZC3HAV1 Antibody LS-C489915

Antibody:

PARP13 / ZC3HAV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

50 µl/$317; 100 µl/$375; 200 µl/$473

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Human PARP13 / ZC3HAV1 Protein (Recombinant GST) (Full Length) - LS-G34576

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.3 kDa

Price:

2 µg/$439

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Human PARP13 / ZC3HAV1 Protein (Recombinant GST, N-terminus) (aa601-699) - LS-G62863

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

Select

Human PARP13 / ZC3HAV1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91176

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.3 kDa

Price:

20 µg/$215

Select

PARP13 / ZC3HAV1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.3 kDa

Price:

100 µg/$710

Viewing 1-18 of 18 product results

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