PARN

poly(A)-specific ribonuclease

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PARN (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-GST-S (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human PARN Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G21036

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

77.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PARN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89138

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.3 kDa

Price:

20 µg/$150

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PARN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117888

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.3 kDa

Price:

100 µg/$494

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Human PARN Protein (Recombinant GST) (Full Length) - LS-G29624

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

96.03 kDa

Price:

2 µg/$439

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Human PARN Protein (Recombinant His) (Full Length) - LS-G23064

Source:

Yeast

Tag:

His

Molecular Weight:

75.4 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human PARN Protein (Recombinant His-GST-S) (aa178-245) - LS-G24663

Source:

E. coli

Tag:

His-GST-S

Molecular Weight:

38.1 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human PARN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71190

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.3 kDa

Price:

20 µg/$1,107

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Human PARN Protein (Recombinant GST, N-terminus) (aa501-599) - LS-G59504

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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