PARK7 / DJ-1

parkinson protein 7

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.

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Products

Proteins (14)

Type

Over-Expression Lysate (4)

Recombinant (10)

Target

PARK7 / DJ-1 (14)

Publications

No (14)

Tag

GST (2)

GST, N-terminus (1)

His (4)

His,C-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (10)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (6)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (4)

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Human PARK7 / DJ-1 Protein (Recombinant His) - LS-G3530

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PARK7 / DJ-1 Protein (Recombinant GST) (Full Length) - LS-G22221

Source:

E. coli

Tag:

GST

Molecular Weight:

47.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PARK7 / DJ-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67619

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$1,107

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PARK7 / DJ-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124479

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

100 µg/$494

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Human PARK7 / DJ-1 Protein (Recombinant His) (aa1-189) - LS-G16107

Source:

E. coli

Tag:

His

Molecular Weight:

21.4 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Mouse PARK7 / DJ-1 Protein (Recombinant His) (aa1-189) - LS-G16108

Source:

E. coli

Tag:

His

Molecular Weight:

21.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat PARK7 / DJ-1 Protein (Recombinant His) (aa1-189) - LS-G16112

Source:

E. coli

Tag:

His

Molecular Weight:

21.4 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human PARK7 / DJ-1 Protein (Recombinant GST) (Full Length) - LS-G32604

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PARK7 / DJ-1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61824

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PARK7 / DJ-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67620

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$1,107

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Human PARK7 / DJ-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80293

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$150

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Human PARK7 / DJ-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80294

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

20 µg/$150

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PARK7 / DJ-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101006

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.7 kDa

Price:

100 µg/$494

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Human PARK7 / DJ-1 Protein (Recombinant His,C-terminus) (Met1-Asp189) - LS-G137955

Source:

E. coli

Tag:

His,C-terminus

Molecular Weight:

21.3 kDa

Price:

100 µg/$532

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