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PARK7 / DJ-1

parkinson protein 7

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.

Gene Name: parkinson protein 7
Synonyms: PARK7, DJ-1, DJ1, Parkinson disease protein 7, Park-7, Oncogene DJ1, Parkinson protein 7, Protein DJ-1
Target Sequences: NM_007262 NP_009193.2 Q99497

Publications (10)

1
Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J. Molecular & cellular proteomics : MCP. 2007 6:845-59. [PubMed:16854843]
2
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Hong Z, Shi M, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Leverenz JB, Baird G, Montine TJ, Hancock AM, Hwang H, Pan C, Bradner J, Kang UJ, Jensen PH, Zhang J. Brain : a journal of neurology. 2010 133:713-26. [PubMed:20157014] [PMC:PMC2842513]
3
DJ-1 mediates paraquat-induced dopaminergic neuronal cell death. Kwon HJ, Heo JY, Shim JH, Park JH, Seo KS, Ryu MJ, Han JS, Shong M, Son JH, Kweon GR. Toxicology letters. 2011 202:85-92. (WB; Mouse) [PubMed:21300143]
4
DJ-1 associates with synaptic membranes. Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N. Neurobiology of disease. 2011 43:651-62. [PubMed:21645620]
5
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease. Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H. Journal of neuropathology and experimental neurology. 2011 70:686-97. (WB; Mouse) [PubMed:21760537]
6
Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production. Cuevas S, Zhang Y, Yang Y, Escano C, Asico L, Jones JE, Armando I, Jose PA. Hypertension. 2012 59:446-52. [PubMed:22215708] [PMC:PMC3395064]
7
DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly. Heo JY, Park JH, Kim SJ, Seo KS, Han JS, Lee SH, Kim JM, Park JI, Park SK, Lim K, Hwang BD, Shong M, Kweon GR. PloS one. 2012 7:e32629. (WB; Mouse) [PubMed:22403686] [PMC:PMC3293835]
8
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Kim SJ, Park YJ, Hwang IY, Youdim MB, Park KS, Oh YJ. Free radical biology & medicine. 2012 53:936-50. (ICC; Mouse) [PubMed:22683601]
9
DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Lin X, Cook TJ, Zabetian CP, Leverenz JB, Peskind ER, Hu SC, Cain KC, Pan C, Edgar JS, Goodlett DR, Racette BA, Checkoway H, Montine TJ, Shi M, Zhang J. Scientific reports. 2012 2:954. (WB, IP; Human) [PubMed:23233873] [PMC:PMC3518819]
10
Parkinson Disease Protein 7 (PARK7) Is Related to the Ability of Mammalian Sperm to Undergo In Vitro Capacitation. Sandra Recuero , Ariadna Delgado-Bermúdez , Yentel Mateo-Otero , Estela Garcia-Bonavila , Marc Llavanera , Marc Yeste. International journal of molecular sciences. 2021 Oct;22:10804. [Full Text Article] [PubMed:34639144] [PMC:PMC8509420] Related Antibodies: LS-C353340.
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PARK7 / DJ-1 Antibody - Anti-PARK7 / DJ-1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Chimpanzee, African green monkey, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
PARK7 / DJ-1 Antibody - Immunohistochemical analysis of DJ-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Bovine, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
PARK7 / DJ-1 Antibody - Western blot of PARK7 antibody
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (40-120 aa, Internal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PARK7 / DJ-1 Antibody - Jurkat cell lysate was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Park7/DJ-1 antibody (1:1000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and aN ECL detection system.
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PARK7 / DJ-1 Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
PARK7 / DJ-1 Antibody - Anti-PARK7 / DJ-1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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PARK7 / DJ-1 Goat anti-Human Polyclonal (aa178-189) Antibody
Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
PARK7 / DJ-1 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
PARK7 / DJ-1 Mouse anti-Human Monoclonal (4H4) Antibody
Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PARK7 / DJ-1 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
PARK7 / DJ-1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
PARK7 / DJ-1 Mouse anti-Human Monoclonal (3E8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
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PARK7 / DJ-1 Rabbit anti-Rat Monoclonal (4H4) Antibody
Mouse, Bovine, Rat, Human
IF, WB
Unconjugated
100 µl/$469
PARK7 / DJ-1 Antibody - Immunofluorescence analysis of HeLa cells using PARK7 antibody. Blue: DAPI for nuclear staining.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Unconjugated
20 µl/$287; 100 µl/$431
PARK7 / DJ-1 Antibody - Immunohistochemical analysis of DJ-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rat, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
PARK7 / DJ-1 Antibody - Immunohistochemistry - Anti-PARK7 / DJ1 Picoband Antibody
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PARK7 / DJ-1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PARK7 / DJ-1 Antibody - PARK7 antibody IHC-paraffin: Mouse Pancreas Tissue.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (aa2-189) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PARK7 / DJ-1 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using DJ-1 antibody.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF, IP, WB
Unconjugated
20 µl/$271; 100 µl/$412
PARK7 / DJ-1 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using DJ-1 Antibody. The picture on the right is blocked with the synthesized peptide.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PARK7 / DJ-1 Antibody - ICC/IF analysis of PARK7 in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human PARK7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).ICC/IF analysis of PARK7 in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human PARK7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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PARK7 / DJ-1 Mouse anti-Human Monoclonal (AT1E12) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
PARK7 / DJ-1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (aa 1-188) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PARK7 / DJ-1 Antibody - IHC of DJ-1/PARK7 (P54) pAb in paraffin-embedded human lung carcinoma tissue.
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (Pro54) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
PARK7 / DJ-1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PARK7 / DJ-1 Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PARK7 / DJ-1 Antibody - Confocal immunofluorescence of DJ-1 Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ICC, IF, WB
Unconjugated
400 µl/$393
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
40 µg/$485
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PARK7 / DJ-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
40 µg/$485
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).