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Unfortunately, the antibody (ID:228943) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PARK2 / Parkin

parkin RBR E3 ubiquitin protein ligase

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Gene Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PARK2, AR-JP, LPRS2, Parkin, PDJ, Parkinson disease protein 2, PRKN
Target Sequences: NM_004562 NP_004553.2 O60260
Featured Image

Featured PARK2 / Parkin Antibody

LS-B7045 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (1)

1
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Bian M, Liu J, Hong X, Yu M, Huang Y, Sheng Z, Fei J, Huang F. PloS one. 2012 7:e39953. [PubMed:22792139] [PMC:PMC3390003] Related Antibodies: LS-C99184.

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, ELISA aa1-50 No Primary
Anti-PARK2 / Parkin Antibody (aa1-50) IHC-plus™ LS-B7045
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Mouse, Human, Rat IHC-P, WB aa311-360 No Primary
Anti-PARK2 / Parkin Antibody (aa311-360) IHC-plus™ LS-B5889
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal to Mouse PARK2 / Parkin
Mouse, Human, Rat
IHC - Paraffin, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB, Flo C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus) LS-C99185
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB, Flo N-Terminus Yes Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C99184
PublicationsPublications (1)
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, Flo, ELISA aa300-350 No Primary
Anti-PARK2 / Parkin Antibody (aa300-350) LS-C203086
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Mouse, Rat
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C335118
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA aa101-150 No Primary
Anti-PARK2 / Parkin Antibody (aa101-150) LS-C117690
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA pSer131 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser131) LS-C199412
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa229-465 No Primary
Anti-PARK2 / Parkin Antibody (aa229-465) LS-C373741
Western blot Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C192292
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB, ELISA aa1-80 No Primary
Anti-PARK2 / Parkin Antibody (aa1-80) LS-C385373
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Bovine IHC, ICC, IF, WB Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C368456
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Bovine
IHC, ICC, Immunofluorescence, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human IHC, IF, WB, ELISA N-Terminus No Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C336191
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal 5A1 Unconjugated Human IHC, WB, IP No Primary
Anti-PARK2 / Parkin Antibody (clone 5A1) LS-C193601
Mouse Monoclonal [clone 5A1] (IgG1) to Human PARK2 / Parkin
Human
IHC, Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Goat IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA aa83-97 No Primary
Anti-PARK2 / Parkin Antibody (aa83-97) LS-C27055
Goat Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA aa62-80 No Primary
Anti-PARK2 / Parkin Antibody (aa62-80) LS-C40765
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA aa70-150 No Primary
Anti-PARK2 / Parkin Antibody (aa70-150) LS-C385374
Western blot Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA pSer131 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser131) LS-C381552
Western blot Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, ICC, WB aa23-416 No Primary
Anti-PARK2 / Parkin Antibody (aa23-416) LS-C357496
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA aa300-350 No Primary
Anti-PARK2 / Parkin Antibody (aa300-350) LS-C93067
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, IP No Primary
Anti-PARK2 / Parkin Antibody LS-C74153
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
IHC, Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal Unconjugated Human, Mouse IHC, WB, ELISA No Primary
Anti-PARK2 / Parkin Antibody LS-C124347
Mouse Monoclonal (IgG1) to Human PARK2 / Parkin
Human, Mouse
IHC, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine IHC, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C93066
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Monkey, Mouse, Rat, Bovine
IHC, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Monkey, Rat, Bovine IHC, WB No Primary
Anti-PARK2 / Parkin Antibody LS-C93065
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Monkey, Rat, Bovine
IHC, Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC N-Terminus No Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C189151
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Mouse, Rat
IHC
Unconjugated
PARK2 / Parkin Mouse IgG3,k Monoclonal 1H4 Unconjugated Human IF, WB, ELISA No Primary
Anti-PARK2 / Parkin Antibody (clone 1H4) LS-C197846
Immunofluorescence Image
Western blot Image
Mouse Monoclonal [clone 1H4] (IgG3,k) to Human PARK2 / Parkin
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C2827
Western blot Image
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Goat Polyclonal Unconjugated Human WB, ELISA Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C55234
Western blot Image
Goat Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB pSer378 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser378) LS-C53475
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Bovine WB pSer101 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser101) LS-C53474
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Bovine
Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human, Monkey, Rat, Bovine, Pig ICC, IF, WB N-Terminus No Primary
Anti-PARK2 / Parkin Antibody (N-Terminus) LS-C352631
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal to Human PARK2 / Parkin
Human, Monkey, Rat, Bovine, Pig
ICC, Immunofluorescence, Western blot
Unconjugated
PARK2 / Parkin Goat Polyclonal Unconjugated Human WB, ELISA aa83-97 No Primary
Anti-PARK2 / Parkin Antibody (aa83-97) LS-C85930
Goat Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Mouse IgG1 Monoclonal 1A1 Unconjugated Human, Mouse, Rat WB, IP No Primary
Anti-PARK2 / Parkin Antibody (clone 1A1) LS-C193600
Mouse Monoclonal [clone 1A1] (IgG1) to Human PARK2 / Parkin
Human, Mouse, Rat
Western blot, Immunoprecipitation
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal FITC Conjugated Human ELISA aa1-465 No Primary
Anti-PARK2 / Parkin Antibody (aa1-465, FITC) LS-C370100
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
ELISA
FITC Conjugated
PARK2 / Parkin Rabbit IgG Polyclonal HRP Conjugated Human ELISA aa1-465 No Primary
Anti-PARK2 / Parkin Antibody (aa1-465, HRP) LS-C370102
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
ELISA
HRP Conjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus) LS-C94428
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human, Mouse, Rat
Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB aa28-258 No Primary
Anti-PARK2 / Parkin Antibody (aa28-258) LS-C311769
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Biotin Conjugated Human ELISA aa1-465 No Primary
Anti-PARK2 / Parkin Antibody (aa1-465, Biotin) LS-C370098
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
ELISA
Biotin Conjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human ELISA aa1-465 No Primary
Anti-PARK2 / Parkin Antibody (aa1-465) LS-C370099
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
ELISA
Unconjugated
PARK2 / Parkin Mouse Monoclonal PRK109 Unconjugated Human, Mouse, Rat IF, WB, IP, ELISA C-Terminus No Primary
Anti-PARK2 / Parkin Antibody (C-Terminus, clone PRK109) LS-C38090
Mouse Monoclonal [clone PRK109] to Human PARK2 / Parkin
Human, Mouse, Rat
Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
PARK2 / Parkin Mouse IgG2a Monoclonal Unconjugated Human WB, ELISA aa1-437 No Primary
Anti-PARK2 / Parkin Antibody (aa1-437) LS-C38091
Mouse Monoclonal (IgG2a) to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB, ELISA aa81-98 No Primary
Anti-PARK2 / Parkin Antibody (aa81-98) LS-C93069
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot, ELISA
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB pSer101 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser101) LS-C131307
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit IgG Polyclonal Unconjugated Human WB pSer378 No Primary
Anti-PARK2 / Parkin Antibody (phospho-Ser378) LS-C131306
Rabbit Polyclonal (IgG) to Human PARK2 / Parkin
Human
Western blot
Unconjugated
PARK2 / Parkin Rabbit Polyclonal Unconjugated Human WB Internal No Primary
Anti-PARK2 / Parkin Antibody (Internal) LS-C93062
Rabbit Polyclonal to Human PARK2 / Parkin
Human
Western blot
Unconjugated
Target Corresponding Antibodies
PARK2 / Parkin
PARK2 / Parkin Antibody Blocking Peptide - LS-E8222
LS-E8222
PARK2 / Parkin
LS-C99184
PARK2 / Parkin
PARK2 / Parkin Antibody Blocking Peptide - LS-E8223
LS-E8223
PARK2 / Parkin
LS-C99185
PARK2 / Parkin
PARK2 / Parkin Antibody Blocking Peptide - LS-E15840
LS-E15840
PARK2 / Parkin
LS-B5889
PARK2 / Parkin
PARK2 / Parkin Antibody Blocking Peptide - LS-E26176
LS-E26176
PARK2 / Parkin
LS-C55234
Type Target Reactivity Sample Type
Cell-Based PARK2 / Parkin Human Adherent Cell Cultures
Human PARK2 / Parkin ELISA Kit (Cell-Based ELISA) - LS-F2224
 Image
 Image
Cell-Based ELISA
96-Well Microplate
Human
Colorimetric - 450nm
Adherent Cell Cultures
Sandwich PARK2 / Parkin Human Tissue Homogenates
Human PARK2 / Parkin ELISA Kit (Sandwich ELISA) - LS-F8423
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
0.156-10 ng/ml
Colorimetric - 450nm
Tissue Homogenates
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant PARK2 / Parkin His Human E. coli
Human PARK2 / Parkin Recombinant (His) Protein - LS-G2736
E. coli Expression System
His
Unpurified / Lyophilized
Over-Expression Lysate PARK2 / Parkin His Human
PARK2 / Parkin Over-Expression Lysate (His) Protein - LS-G6387
Human HEK 293 Cells
His
Unpurified / Lyophilized

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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