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PAPPA2 / Pappalysin 2 is a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.
Gene Name: | pappalysin 2 |
Synonyms: | PAPPA2, PAPP-A2, PAPP-E, PLAC3, Pappalysin-2, PAPPE, Placenta-specific 3, Pappalysin 2 |
Target Sequences: | NP_068755.2 Q9BXP8 |
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