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PAPPA / PAPP-A

pregnancy-associated plasma protein A, pappalysin 1

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Gene Name: pregnancy-associated plasma protein A, pappalysin 1
Family/Subfamily: Protease , Metallopeptidase M43
Synonyms: PAPPA, DIPLA1, IGF-dependent IGFBP-4 protease, PAPPA1, PAPA, PAPP-A, Pappalysin-1, ASBABP2, IGFBP-4ase
Target Sequences: NM_002581 NP_002572.2 Q13219

Publications (1)

1
Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos. Vijay Pratap Singh, Sean McKinney, Jennifer L Gerton. The Breast : official journal of the European Society of Mastology. 2020 Aug;54:333-347.e7. [Full Text Article] [PubMed:32800293]

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Products
Proteins (6)
Recombinant (6)
PAPPA / PAPP-A (6)
No (6)
GST, N-terminus (1)
His (3)
His-GST, N-terminus (1)
Myc-DDK (Flag) (1)
Human (5)
Mouse (1)
E. coli (4)
HEK 293 Cells (1)
Wheat Germ Extract (1)
PAPPA / PAPP-A Protein - Recombinant Pregnancy Associated Plasma Protein A By SDS-PAGE
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E. coli
His-GST, N-terminus
62.2 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
PAPPA / PAPP-A Protein - Purified recombinant protein PAPPA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
178.6 kDa
20 µg/$1,107
PAPPA / PAPP-A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PAPPA / PAPP-A Protein - Recombinant Pregnancy Associated Plasma Protein A By SDS-PAGE
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E. coli
His
33.4 kDa
10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
PAPPA / PAPP-A Protein - Recombinant Pregnancy Associated Plasma Protein A By SDS-PAGE
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E. coli
His
26.1 kDa
10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$3,089
PAPPA / PAPP-A Protein - Recombinant Pregnancy Associated Plasma Protein A By SDS-PAGE
Select
E. coli
His
30.9 kDa
10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).