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PAPPA / PAPP-A

pregnancy-associated plasma protein A, pappalysin 1

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Gene Name: pregnancy-associated plasma protein A, pappalysin 1
Family/Subfamily: Protease , Metallopeptidase M43
Synonyms: PAPPA, DIPLA1, IGF-dependent IGFBP-4 protease, PAPPA1, PAPA, PAPP-A, Pappalysin-1, ASBABP2, IGFBP-4ase
Target Sequences: NM_002581 NP_002572.2 Q13219

Publications (1)

1
Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos. Vijay Pratap Singh, Sean McKinney, Jennifer L Gerton. The Breast : official journal of the European Society of Mastology. 2020 Aug;54:333-347.e7. [Full Text Article] [PubMed:32800293]

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Products
ELISA Kits (20)
Competitive EIA (1)
Custom (1)
Sandwich (16)
Sandwich CLIA (2)
PAPPA / PAPP-A (20)
Human (8)
Mouse (6)
Rat (2)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (4)
96-Well Strip Plate (14)
No (19)
Yes (1)
Cell Culture Supernatants (1)
Plasma (16)
Serum (16)
Tissue Homogenates (4)
Urine (1)
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
PAPPA / PAPP-A ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
PAPPA / PAPP-A ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PAPPA / PAPP-A ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.7 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$1,041
PAPPA / PAPP-A ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.686 - 166.7 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).