PAP2a / PPAP2A

phosphatidic acid phosphatase type 2A

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PAP2a / PPAP2A (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PAP2a / PPAP2A Protein (Recombinant GST) (Full Length) - LS-G31233

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.98 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PAP2a / PPAP2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76647

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32 kDa

Price:

20 µg/$150

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PAP2a / PPAP2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117139

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32 kDa

Price:

100 µg/$494

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