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PAOX / PAO
polyamine oxidase (exo-N4-amino)
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N1,N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
| Gene Name: | polyamine oxidase (exo-N4-amino) |
| Synonyms: | PAOX, PAO, Polyamine oxidase |
| Target Sequences: | AA418209 Q6QHF9 Q6QHF9 |
Publications (1)
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