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PAN2 / USP52
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
| Gene Name: | PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) |
| Synonyms: | PAN2, PYPAF4, Ubiquitin specific protease 52, USP52 |
| Target Sequences: | NM_001127460 NP_001120932.1 Q504Q3 |
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