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PAK7/PAK5
p21 protein (Cdc42/Rac)-activated kinase 7
PAK7 is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
| Gene Name: | p21 protein (Cdc42/Rac)-activated kinase 7 |
| Family/Subfamily: | Protein Kinase , PAK (STE20) |
| Synonyms: | PAK7/PAK5, p21(CDKN1A)-activated kinase 7, p21CDKN1A-activated kinase 7, PAK7, PAK-7, PAK5, KIAA1264, p21-activated kinase 5, PAK-5, p21-activated kinase 7, Protein kinase PAK5 |
| Target Sequences: | NM_020341 NP_065074.1 Q9P286 |
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