PAK4

p21 protein (Cdc42/Rac)-activated kinase 4

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

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Products

Proteins (15)

Type

Over-Expression Lysate (8)

Recombinant (7)

Target

PAK4 (15)

Publications

No (15)

Tag

GST, N-terminus (1)

His (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (11)

Species

Human (11)

Source

293T Cells (4)

E. coli (3)

HEK 293 Cells (7)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human PAK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70302

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$1,107

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Human PAK4 Protein (Recombinant His) - LS-G3508

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121599

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

100 µg/$494

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PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121601

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

100 µg/$710

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PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121600

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

100 µg/$494

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Human PAK4 Protein (Recombinant GST, N-terminus) (aa68-157) - LS-G61463

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86726

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$150

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Human PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86728

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$150

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Human PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86729

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$215

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Human PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86731

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$150

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PAK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115665

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

100 µg/$494

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Human PAK4 Protein (Recombinant His-SUMO) (aa1-426) - LS-G21034

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

63.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PAK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70301

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$1,107

Select

Human PAK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70303

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.9 kDa

Price:

20 µg/$1,107

Select

Human PAK4 Protein (Recombinant His-T7) (aa299-542) - LS-G15891

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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