PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation.

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Proteins (9)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (5)

Target

PAK1 (9)

Publications

No (9)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PAK1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21650

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

76.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PAK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.5 kDa

Price:

20 µg/$1,107

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Human PAK1 Protein (Recombinant GST, N-terminus) (aa191-280) - LS-G59497

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PAK1 Protein (Recombinant His-T7) (aa252-501) - LS-G15905

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.9 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human PAK1 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ser2-Leu546) - LS-G26949

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

63 kDa

Price:

200 µl/$283

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Human PAK1 Protein (Recombinant GST) (Full Length) - LS-G29619

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PAK1 Protein (Over-Expression Lysate 6His, N-terminus) (Ser2-Leu546) - LS-G26813

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

63 kDa

Price:

100 µg/$298

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PAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124830

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.5 kDa

Price:

100 µg/$494

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Human PAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.5 kDa

Price:

20 µg/$150

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