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PAIP2B
poly(A) binding protein interacting protein 2B
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
| Gene Name: | poly(A) binding protein interacting protein 2B |
| Synonyms: | PAIP2B, KIAA1155, PABP-interacting protein 2B, PAIP-2B |
| Target Sequences: | NM_020459 NP_065192.1 Q9ULR5 |
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