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PAIP2

poly(A) binding protein interacting protein 2

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.

Gene Name:	poly(A) binding protein interacting protein 2
Synonyms:	PAIP2, PABC1-interacting protein 2, PAIP-2, PAIP2A, PABP-interacting protein 2
Target Sequences:	NM_016480 NP_057564.3 Q9BPZ3

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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