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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PAICS / ADE2

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

PAICS / ADE2 encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Synonyms: PAICS, ADE2, ADE2H1, AIR carboxylase, AIRC, Multifunctional protein ADE2H1, PAIS, Multifunctional protein ADE2, SAICAR synthetase
Target Sequences: NM_006452 NP_006443.1 P22234

Filtered by: None
Target
PAICS / ADE2 (30)
Reactivity
Human (30)
Mouse (19)
Rat (6)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (4)
Application
IHC (18)
IHC-P (4)
WB (30)
Flo (16)
ELISA (11)
ICC (1)
IF (11)
IP (1)
Host
rabbit (22)
mouse (8)
Isotype
IgG (19)
IgG1 (2)
IgG2b (6)
Clonality
monoclonal mc (8)
polyclonal pc (22)
Clone
1B4 (2)
OTI2C9 (2)
OTI5B6 (2)
OTI8A1 (2)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
Carrier-free (4)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (21)
Epitope
aa95-123 (8)
N-Terminus (4)
aa1-50 (1)
aa300-350 (1)
Publications
No (30)
Showing 1-25 of 30 results

IHC-plus™ PAICS / ADE2 Antibody (clone 1B4) LS-B8778
Mouse Monoclonal [clone 1B4] (IgG2b) to Human PAICS / ADE2
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-PAICS / ADE2 antibody IHC staining of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.

IHC-plus™ PAICS / ADE2 Antibody LS-B16062
Rabbit Polyclonal to Human PAICS / ADE2
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of ADE2 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.

PAICS / ADE2 Antibody LS-C334729
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat spleen tissue.
Immunofluorescence analysis of U2OS cells.

PAICS / ADE2 Antibody (aa95-123) LS-C163343
Rabbit Polyclonal to Human PAICS / ADE2
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
PAICS Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
PAICS Antibody western blot of K562 cell line lysates (35 ug/lane). The PAICS antibody detected the PAICS protein (arrow).

PAICS / ADE2 Antibody (clone 1B4, Carrier-free) LS-C784842
Mouse Monoclonal [clone 1B4] (IgG2b) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PAICS / ADE2 antibody IHC staining of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.

PAICS / ADE2 Antibody (aa95-123) LS-C329942
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

PAICS / ADE2 Antibody (aa95-123, Biotin) LS-C265501
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl  $740.00

PAICS / ADE2 Antibody (aa95-123, FITC) LS-C265502
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

PAICS / ADE2 Antibody (aa95-123, APC) LS-C265499
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl  $740.00

PAICS / ADE2 Antibody (aa95-123, AP) LS-C265500
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl  $740.00

PAICS / ADE2 Antibody (aa95-123, Azide-free, HRP) LS-C265503
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

PAICS / ADE2 Antibody (aa95-123, PE) LS-C265516
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl  $740.00

PAICS / ADE2 Antibody LS-C667438
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Human
ELISA, Flo, IHC, WB
Unconjugated
100µg  $335.00

PAICS / ADE2 Antibody (clone OTI8A1) LS-C115446
Mouse Monoclonal [clone OTI8A1] (IgG2b) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated
100µl 1mg/ml  $345.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody (clone OTI8A1, Carrier-free) LS-C784839
Mouse Monoclonal [clone OTI8A1] (IgG2b) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody (clone OTI2C9) LS-C115458
Mouse Monoclonal [clone OTI2C9] (IgG1) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated
100µl 0.63mg/ml  $345.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody (clone OTI2C9, Carrier-free) LS-C784854
Mouse Monoclonal [clone OTI2C9] (IgG1) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody LS-C676219
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100

PAICS / ADE2 Antibody LS-C768838
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

PAICS / ADE2 Antibody (clone OTI5B6) LS-C115444
Mouse Monoclonal [clone OTI5B6] (IgG2b) to Human PAICS / ADE2
Human
IF, WB
Unconjugated
100µl 1mg/ml  $345.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody (clone OTI5B6, Carrier-free) LS-C784840
Mouse Monoclonal [clone OTI5B6] (IgG2b) to Human PAICS / ADE2
Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg  $395.00
Anti-PAICS mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PAICS.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PAICS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PAICS.

PAICS / ADE2 Antibody LS-C401917
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.8mg/ml  $205.00; 60µl 0.8mg/ml  $235.00; 120µl 0.8mg/ml  $295.00; 200µl 0.8mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using PAICS Polyclonal Antibody at dilution of 1:35.
Immunohistochemistry of paraffin-embedded Human breast cancer using PAICS Polyclonal Antibody at dilution of 1:35.

PAICS / ADE2 Antibody LS-C405229
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.2mg/ml  $205.00; 60µl 0.2mg/ml  $235.00; 120µl 0.2mg/ml  $295.00; 200µl 0.2mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human cervical cancer using PAICS Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of paraffin-embedded Human esophagus cancer using PAICS Polyclonal Antibody at dilution of 1:50.

PAICS / ADE2 Antibody (aa1-50) LS-C762068
Rabbit Polyclonal (IgG) to Human PAICS / ADE2
Human
IHC, IP, WB
Unconjugated
100µg 100µl 1mg/ml  $395.00
Detection of human ADE2 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ADE2 antibody used for WB at 0.1 µg/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

PAICS / ADE2 Antibody LS-C412372
Rabbit Polyclonal to Human PAICS / ADE2
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00
Western blot of PAICS polyclonal antibody.
Showing 1-25 of 30 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).