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PADI3 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.
Gene Name: | peptidyl arginine deiminase, type III |
Synonyms: | PADI3, PAD3, PDI3, Peptidylarginine deiminase III |
Target Sequences: | NM_016233 NP_057317.2 Q9ULW8 |
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