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PACSIN2
protein kinase C and casein kinase substrate in neurons 2
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
| Gene Name: | protein kinase C and casein kinase substrate in neurons 2 |
| Synonyms: | PACSIN2, SDPII, Syndapin II |
| Target Sequences: | NM_007229 NP_009160.2 Q9UNF0 |
Publications (1)
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