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Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
Gene Name: | phosphofurin acidic cluster sorting protein 1 |
Synonyms: | PACS1, KIAA1175, PACS-1 |
Target Sequences: | NM_018026 NP_060496.2 Q6VY07 |
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