Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
PABPN1 / PABP2
poly(A) binding protein, nuclear 1
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.
| Gene Name: | poly(A) binding protein, nuclear 1 |
| Synonyms: | PABPN1, PABP2, Poly(A)-binding protein 2, OPMD, PABII, PABP-2, Poly(A) binding protein 2, Poly(A) binding protein II, Poly(A)-binding protein II, PAB2 |
| Target Sequences: | NM_004643 NP_004634.1 Q86U42 |
Publications (3)
1
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. Riaz M, Raz Y, van Putten M, Paniagua-Soriano G, Krom YD, Florea BI, Raz V. PLoS genetics. 2016 12:e1006031. (ICC; Human)
[Full Text Article]
[PubMed:27152426]
[PMC:PMC4859507]
Related Antibodies: LS-B8482.
2
Dysfunctional transcripts are formed by alternative polyadenylation in OPMD. Raz V, Dickson G, 't Hoen PAC. Oncotarget. 2017 8:73516-73528. (ICC; Human)
[Full Text Article]
[PubMed:29088723]
Related Antibodies: LS-B8482.
3
Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability. Cyriel Sebastiaan Olie, Erik van der Wal, Domagoj Cikes, Loes Maton, Jessica C de Greef, I-Hsuan Lin, Yi-Fan Chen, Elsayad Kareem, Josef M Penninger, Benedikt M Kessler, Vered Raz. Scientific reports. 2020 October;10:17621. [Full Text Article]
[PubMed:33077830]
[PMC:PMC7572364]
Related Antibodies: LS-B8482.
☰ Filters
Products
Antibodies
(20)
Type
Primary
(20)
Target
PABPN1 / PABP2
(20)
Reactivity
Human
(19)
Mouse
(8)
Rat
(5)
Bovine
(3)
Chimpanzee
(3)
Cow
(2)
Dog
(3)
Guinea pig
(3)
Monkey
(3)
Pig
(3)
Rabbit
(3)
Application
IHC
(7)
IHC-P
(5)
WB
(20)
Flo
(1)
ELISA
(7)
ICC
(1)
IF
(1)
IP
(2)
Peptide-ELISA
(1)
Host
rabbit
(20)
Product Group
IHCPlus
(2)
Isotype
IgG
(13)
Clonality
monoclonal mc
(1)
polyclonal pc
(19)
Clone
EP3001Y
(1)
Format
APC Conjugated
(1)
Azide-free
(1)
Biotin Conjugated
(2)
FITC Conjugated
(2)
HRP Conjugated
(2)
PE Conjugated
(1)
Unconjugated
(12)
Epitope
aa270-298
(7)
N-Terminus
(4)
Internal
(1)
Ser150
(1)
aa1-50
(1)
aa100-150
(1)
Publications
No
(19)
Yes
(1)
PABPN1 / PABP2 Rabbit anti-Human Monoclonal (Internal) (EP3001Y) Antibody
Mouse, Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PABPN1 / PABP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
PABPN1 / PABP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
PABPN1 / PABP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (Ser150) Antibody
Mouse, Rat, Cow, Human
WB
Unconjugated
100 µg/$357
PABPN1 / PABP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Cow, Human
WB
Unconjugated
100 µg/$357
PABPN1 / PABP2 Rabbit anti-Human Polyclonal (aa270-298) Antibody
Human
WB
Unconjugated
400 µl/$393
PABPN1 / PABP2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
Viewing 1-20
of 20
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
