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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PABPN1 / PABP2

poly(A) binding protein, nuclear 1

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.

Gene Name: poly(A) binding protein, nuclear 1
Synonyms: PABPN1, PABP2, Poly(A)-binding protein 2, OPMD, PABII, PABP-2, Poly(A) binding protein 2, Poly(A) binding protein II, Poly(A)-binding protein II, PAB2
Target Sequences: NM_004643 NP_004634.1 Q86U42

Publications (2)

1
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. Riaz M, Raz Y, van Putten M, Paniagua-Soriano G, Krom YD, Florea BI, Raz V. PLoS genetics. 2016 12:e1006031. (ICC; Human) [Full Text Article] [PubMed:27152426] [PMC:PMC4859507] Related Antibodies: LS-B8482.
2
Dysfunctional transcripts are formed by alternative polyadenylation in OPMD. Raz V, Dickson G, 't Hoen PAC. Oncotarget. 2017 8:73516-73528. (ICC; Human) [Full Text Article] [PubMed:29088723] Related Antibodies: LS-B8482.

Filtered by: None
Target
PABPN1 / PABP2 (21)
Reactivity
Human (21)
Mouse (7)
Rat (6)
Bovine (4)
Chimpanzee (3)
Cow (2)
Dog (4)
Guinea pig (4)
Monkey (4)
Pig (4)
Rabbit (4)
Application
IHC (7)
IHC-P (5)
WB (21)
Flo (1)
ELISA (9)
ICC (1)
IF (1)
IP (2)
Host
rabbit (21)
Isotype
IgG (14)
Clonality
monoclonal mc (1)
polyclonal pc (20)
Clone
EP3001Y (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (12)
Epitope
aa270-298 (8)
N-Terminus (4)
Internal (1)
aa1-50 (1)
aa100-150 (1)
Publications
No (20)
Yes (1)
Showing 1-21 of 21 results

IHC-plus™ PABPN1 / PABP2 Antibody (Internal, clone EP3001Y) LS-B8482
Publications (2)
Publications (2)
Rabbit Monoclonal [clone EP3001Y] (IgG) to Human PABPN1 / PABP2
Mouse, Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-PABPN1 / PABP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50-1:100.
Western blot analysis on (A) T47D, (B) SKBR3, (C) Ramos and (D) Raji cell lysates using anti-PABP2 antibody, dilution 1:20000.

IHC-plus™ PABPN1 / PABP2 Antibody (N-Terminus) LS-B5706
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PABPN1 / PABP2 Antibody (N-Terminus, HRP) LS-C440598
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PABPN1 / PABP2 Antibody (N-Terminus, Biotin) LS-C440597
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PABPN1 / PABP2 Antibody (N-Terminus, FITC) LS-C440599
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PABPN1 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PABPN1 / PABP2 Antibody LS-C806878
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Western blot Image

PABPN1 / PABP2 Antibody (aa1-50) LS-C290195
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
IHC, IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00

PABPN1 / PABP2 Antibody (aa100-150) LS-C290196
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
IHC, IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00

PABPN1 / PABP2 Antibody (aa270-298) LS-C323751
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
Unconjugated
200µl  $590.00

PABPN1 / PABP2 Antibody (aa270-298, Biotin) LS-C238624
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

PABPN1 / PABP2 Antibody (aa270-298, FITC) LS-C238625
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

PABPN1 / PABP2 Antibody (aa270-298, AP) LS-C238622
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
AP Conjugated
200µl  $740.00

PABPN1 / PABP2 Antibody (aa270-298, APC) LS-C238623
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
APC Conjugated
200µl  $740.00

PABPN1 / PABP2 Antibody (aa270-298, PE) LS-C238626
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
PE Conjugated
200µl  $740.00

PABPN1 / PABP2 Antibody (aa270-298, Azide-free, HRP) LS-C248389
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

PABPN1 / PABP2 Antibody LS-C781336
Rabbit Polyclonal to Human PABPN1 / PABP2
Mouse, Human
ELISA, WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

PABPN1 / PABP2 Antibody LS-C768835
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

PABPN1 / PABP2 Antibody LS-C777910
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Rat, Cow, Human
WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

PABPN1 / PABP2 Antibody LS-C778081
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Rat, Cow, Human
WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

PABPN1 / PABP2 Antibody (aa270-298) LS-C163334
Rabbit Polyclonal to Human PABPN1 / PABP2
Human
WB
Unconjugated
400µl  $325.00
PABPN1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The PABPN1 antibody detected the PABPN1 protein (arrow).

PABPN1 / PABP2 Antibody LS-C668695
Rabbit Polyclonal to Human PABPN1 / PABP2
Human
WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Western blot Image
Showing 1-21 of 21 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).