Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

PABPN1 / PABP2

poly(A) binding protein, nuclear 1

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.

Gene Name: poly(A) binding protein, nuclear 1
Synonyms: PABPN1, PABP2, Poly(A)-binding protein 2, OPMD, PABII, PABP-2, Poly(A) binding protein 2, Poly(A) binding protein II, Poly(A)-binding protein II, PAB2
Target Sequences: NM_004643 NP_004634.1 Q86U42

Publications (2)

1
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. Riaz M, Raz Y, van Putten M, Paniagua-Soriano G, Krom YD, Florea BI, Raz V. PLoS genetics. 2016 12:e1006031. (ICC; Human) [Full Text Article] [PubMed:27152426] [PMC:PMC4859507] Related Antibodies: LS-B8482.
2
Dysfunctional transcripts are formed by alternative polyadenylation in OPMD. Raz V, Dickson G, 't Hoen PAC. Oncotarget. 2017 8:73516-73528. (ICC; Human) [Full Text Article] [PubMed:29088723] Related Antibodies: LS-B8482.

Viewing 1-21 of 21 items
PABPN1 / PABP2 Antibody - Anti-PABPN1 / PABP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50-1:100.
Select
Rabbit Monoclonal [clone EP3001Y] (IgG) to Human PABPN1 / PABP2
Mouse, Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
PABPN1 / PABP2 Antibody - Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
PABPN1 / PABP2 Antibody - Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
PABPN1 / PABP2 Antibody - Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
PABPN1 / PABP2 Antibody - Anti-PABPN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Rabbit, Dog, Guinea pig, Bovine, Rat, Pig, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
PABPN1 / PABP2 Antibody - Western blot analysis of PABPN1 using A549 whole lysates.
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
IHC, IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
IHC, IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Rat, Cow, Human
WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Rat, Cow, Human
WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human PABPN1 / PABP2
Mouse, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
PABPN1 / PABP2 Antibody
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Human
WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
PABPN1 / PABP2 Antibody - PABPN1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The PABPN1 antibody detected the PABPN1 protein (arrow).
Select
Rabbit Polyclonal to Human PABPN1 / PABP2
Human
WB
Unconjugated
400µl   $325.00

Viewing 1-21 of 21 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).