p84 / THOC1

THO complex 1

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

p84 / THOC1 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human p84 / THOC1 Protein (Recombinant GST, N-terminus) (aa560-657) - LS-G61310

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human p84 / THOC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66715

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

20 µg/$1,107

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Human p84 / THOC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78351

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

20 µg/$150

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p84 / THOC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100458

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.5 kDa

Price:

100 µg/$494

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