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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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p66 / SHC

SHC (Src homology 2 domain containing) transforming protein 1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Gene Name: SHC (Src homology 2 domain containing) transforming protein 1
Synonyms: SHC1, p46 shc, p52 shc, SH2 domain protein C1, p66, SHCA, SHC, SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A
Target Sequences: NM_003029 NP_003020.2 P29353

Publications (1)

1
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L. Scientific reports. 2016 6:29302. (WB; Human) [Full Text Article] [PubMed:27377870] [PMC:PMC4932503] Related Antibodies: LS-C10119.

Filtered by: None
Type
Over-Expression Lysate (8)
Recombinant (5)
Target
p66 / SHC (13)
Tag
6His,N-terminus (1)
GST,N-terminus (1)
His (2)
His + T7 (1)
Myc + DDK (8)
Species
Human (9)
Source
293T Cells (3)
E. coli (3)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purification
Purified (2)
Publications
No (13)
Showing 1-13 of 13 results

p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G124967
HEK 293 Cells
Myc + DDK
51.6 kDa
100µg  $345.00

p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G124966
HEK 293 Cells
Myc + DDK
62.7 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human p66 / SHC Protein (Recombinant His) - LS-G1352
E. coli
His
100µg 1mg/ml  $315.00; 0.5mg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human p66 / SHC Protein (Recombinant GST,N-terminus) (aa171-280) - LS-G60082
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human p66 / SHC Protein (Recombinant Myc + DDK) (Full Length) - LS-G66955
HEK 293 Cells
Myc + DDK
51.5 kDa
20µg  $890.00
Purified recombinant protein SHC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human p66 / SHC Protein (Over-Expression Lysate 6His,N-terminus) (Met111-Leu583) - LS-G26776
HEK 293 Cells
6His,N-terminus
55 kDa
100µg  $245.00

Human p66 / SHC Protein (Recombinant His + T7) (aa272-559) - LS-G25495
E. coli
His + T7
35.4 kDa
10µg  $275.00; 50µg  $455.00; 100µg  $605.00; 200µg  $875.00; 1mg  $2,265.00; 500µg  $1,005.00
Recombinant  SHC-Transforming Protein 1 By SDS-PAGE

Human p66 / SHC Protein (Recombinant His) - LS-G20280
E. coli
His
53.8 kDa
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

Human p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78808
293T Cells
Myc + DDK
62.7 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78809
293T Cells
Myc + DDK
51.5 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78810
293T Cells
Myc + DDK
62.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99944
HEK 293 Cells
Myc + DDK
51.5 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

p66 / SHC Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G104065
HEK 293 Cells
Myc + DDK
62.6 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-13 of 13 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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