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p56lck / LCK

lymphocyte-specific protein tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.

Gene Name: lymphocyte-specific protein tyrosine kinase
Family/Subfamily: Protein Kinase , Src
Synonyms: LCK, Lck kinase, LSK, p56-LCK, Pp58lck, Tyrosine-protein kinase Lck, p56lck, Protein YT16, Proto-oncogene Lck, YT16
Target Sequences: NM_005356 NP_005347.3 P06239

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Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
p56lck / LCK (10)
No (10)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (2)
His-SUMO (1)
Myc-DDK (Flag) (5)
Human (8)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (1)
p56lck / LCK Protein
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E. coli
His-SUMO
77.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
p56lck / LCK Protein - Purified recombinant protein LCK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57.8 kDa
20 µg/$1,107
p56lck / LCK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
p56lck / LCK Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
p56lck / LCK Protein - 12.5% SDS-PAGE of human LCK stained with Coomassie Blue
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Wheat Germ Extract
GST
84.7 kDa
10 µg/$479; 25 µg/$670
p56lck / LCK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57.8 kDa
100 µg/$710
Select
Insect Cells
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.4 kDa
50 µg/$707
p56lck / LCK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.8 kDa
20 µg/$215
p56lck / LCK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.8 kDa
20 µg/$215
p56lck / LCK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57.8 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).