Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
P2RY6 / P2Y6 belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
|Gene Name:||pyrimidinergic receptor P2Y, G-protein coupled, 6|
|Family/Subfamily:||GPCR , Purinergic|
|Synonyms:||P2RY6, G-coupled nucleotide receptor, p2 purinoceptor, p2y3 receptor, p2Y purinoceptor 6, Purinergic receptor p2y6, p2RY6, p2y3 and chick, p2Y6 receptor, p2Y6, Purinoceptor p2y6|
|Target Sequences:||NM_004154 NP_004145.1 Q15077|
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