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P2RX7 / P2X7
purinergic receptor P2X, ligand-gated ion channel, 7
P2RX7 / P2X7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
| Gene Name: | purinergic receptor P2X, ligand-gated ion channel, 7 |
| Family/Subfamily: | Ion Channel , P2X receptor |
| Synonyms: | P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor |
| Target Sequences: | NM_002562 NP_002553.3 Q99572 |
Publications (2)
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