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P2RX3 / P2X3
purinergic receptor P2X, ligand-gated ion channel, 3
P2RX3 / P2X3 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
| Gene Name: | purinergic receptor P2X, ligand-gated ion channel, 3 |
| Family/Subfamily: | Ion Channel , P2X receptor |
| Synonyms: | P2RX3, ATP receptor, p2X3, p2X3 purinoceptor, p2X purinoceptor 3, Purinergic receptor P2X3, Purinoceptor P2X3, Purinergic receptor, p2RX3, p2X receptor 3, p2X receptor, subunit 3 |
| Target Sequences: | NM_002559 NP_002550.2 P56373 |
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