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P2RX1 / P2X1
purinergic receptor P2X, ligand-gated ion channel, 1
P2RX1 / P2X1 belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis.
| Gene Name: | purinergic receptor P2X, ligand-gated ion channel, 1 |
| Family/Subfamily: | Ion channel , P2X receptor |
| Synonyms: | P2RX1, ATP receptor, p2X receptor 1, p2X1, p2X1 purinoceptor, p2X1 receptor, Purinergic receptor, p2RX1, p2X purinoceptor 1, p2X receptor, subunit 1 |
| Target Sequences: | NM_002558 NP_002549.1 P51575 |
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