Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
P2RX1 / P2X1 belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis.
|Gene Name:||purinergic receptor P2X, ligand-gated ion channel, 1|
|Family/Subfamily:||Ion channel , P2X receptor|
|Synonyms:||P2RX1, ATP receptor, p2X receptor 1, p2X1, p2X1 purinoceptor, p2X1 receptor, Purinergic receptor, p2RX1, p2X purinoceptor 1, p2X receptor, subunit 1|
|Target Sequences:||NM_002558 NP_002549.1 P51575|
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