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OXTR / Oxytocin Receptor

oxytocin receptor

The oxytocin receptor belongs to the vasopressin/oxytocin family of GPCRs because it binds similar cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. The activated oxytocin receptor causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. This receptor also plays a role in natriuresis, kaliuresis and may have an antistress effect.

Gene Name: oxytocin receptor
Family/Subfamily: GPCR , Vasopressin/oxytocin
Synonyms: OXTR, Oxytocin receptor, Oxt-r, OT-R
Target Sequences: NM_000916 NP_000907.2 P30559

Publications (2)

1
The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine. Karin Warfvinge, Diana Krause, Lars Edvinsson. The journal of headache and pain. 2020 Feb;21:10. [Full Text Article] [PubMed:32028899] [PMC:PMC7006173] Related Antibodies: LS-C373020.
2
Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Feb;29:2259-71. [Full Text Article] [PubMed:19228979] Related Antibodies: LS-A246.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
OXTR / Oxytocin Receptor (5)
No (5)
His-GST (2)
His-GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
OXTR / Oxytocin Receptor Protein - Recombinant Oxytocin Receptor By SDS-PAGE
Select
E. coli
His-GST, N-terminus
44.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
OXTR / Oxytocin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.6 kDa
20 µg/$150
OXTR / Oxytocin Receptor Protein - Recombinant Oxytocin Receptor By SDS-PAGE
Select
E. coli
His-GST
34.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
OXTR / Oxytocin Receptor Protein - Recombinant Oxytocin Receptor By SDS-PAGE
Select
E. coli
His-GST
39.9 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
OXTR / Oxytocin Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.6 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).