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OX1R / Orexin Receptor 1

hypocretin (orexin) receptor 1

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.

Gene Name: hypocretin (orexin) receptor 1
Family/Subfamily: GPCR , Orexin
Synonyms: HCRTR1, Hcrt receptor 1, Hypocretin receptor 1, Hypocretin type 1 receptor, Hypocretin receptor-1, Orexin receptor type 1, Orexin type 1 receptor, Orexin-1 receptor, OX1 receptor, Orexin a receptor, Orexin receptor-1, OX-R1, Orexin receptor 1, Ox1-R, OX1R, Hypocretin (orexin) receptor 1, Hypocretin receptor type 1, Ox-1-R
Target Sequences: NM_001525 NP_001516.2 O43613

Publications (2)

1
Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A. Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa. Integrative medicine research. 2018 Jun;;7:141-148. [Full Text Article] [PubMed:29989049] [PMC:PMC6035380] Related Antibodies: LS-C385249.
2
Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study. Nir Goldstein, Hiroshi Tsuneki, Nikhil Bhandarkar, Eleonora Aimaretti, Yulia Haim, Kanta Kon, Kiyofumi Sato, Tsutomu Wada, Idit F Liberty, Boris Kirshtein, Oleg Dukhno, Nitzan Maixner, Yftach Gepner, Toshiyasu Sasaoka, Assaf Rudich. Obesity (Silver Spring, Md.). 2021 November;29:1857-1867. [Full Text Article] [PubMed:34472713] Related Antibodies: LS-C292046.

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Products
Proteins (3)
Recombinant (3)
OX1R / Orexin Receptor 1 (3)
No (3)
10His, N-terminus + Myc, C-terminus (1)
6His-SUMOstar, N-terminus (1)
GST (1)
Human (3)
E. coli (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
OX1R / Orexin Receptor 1 Protein - 12.5% SDS-PAGE of human HCRTR1 stained with Coomassie Blue
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Wheat Germ Extract
GST
73.9 kDa
2 µg/$439
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Yeast
6His-SUMOstar, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
OX1R / Orexin Receptor 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
10.4 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).