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OVCA1 / DPH1
diphthamide biosynthesis 1
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival. Expression of DPH2L1 is significantly reduced or undetectable in many ovarian tumors and tumor cell lines.
| Gene Name: | diphthamide biosynthesis 1 |
| Synonyms: | DPH1, DPH-like 1, DPH1 homolog, DPH1 homolog (S. cerevisiae), DPH2-like 1, DPH2L1, DPH-like 1 (S. cerevisiae), DPH2L, OVCA1, HsDph1 |
| Target Sequences: | NM_001383 NP_001374.3 Q9BZG8 |
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