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OVCA1 / DPH1

diphthamide biosynthesis 1

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival. Expression of DPH2L1 is significantly reduced or undetectable in many ovarian tumors and tumor cell lines.

Gene Name: diphthamide biosynthesis 1
Synonyms: DPH1, DPH-like 1, DPH1 homolog, DPH1 homolog (S. cerevisiae), DPH2-like 1, DPH2L1, DPH-like 1 (S. cerevisiae), DPH2L, OVCA1, HsDph1
Target Sequences: NM_001383 NP_001374.3 Q9BZG8

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).