OTUD7B / Cezanne

OTU domain containing 7B

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

OTUD7B / Cezanne (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human OTUD7B / Cezanne Protein (Recombinant GST, N-terminus) (aa759-858) - LS-G62889

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human OTUD7B / Cezanne Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72030

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.3 kDa

Price:

20 µg/$1,107

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Human OTUD7B / Cezanne Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91212

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.3 kDa

Price:

20 µg/$150

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Human OTUD7B / Cezanne Protein (Recombinant GST) (Full Length) - LS-G34620

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74 kDa

Price:

10 µg/$479; 25 µg/$670

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OTUD7B / Cezanne Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111274

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.3 kDa

Price:

100 µg/$494

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