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OTOF / Otoferlin

otoferlin

Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes.

Gene Name:	otoferlin
Synonyms:	OTOF, AUNB1, DFNB6, DFNB9, Otoferlin, Fer-1-like protein 2, FER1L2, NSRD9
Target Sequences:	NM_004802 NP_004793.2 Q9HC10

Publications (1)

GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing. Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, Krämer M, Feil R, Pilz PKD, Knipper M, Rüttiger L. Frontiers in neural circuits. 2018 August;12:65. [Full Text Article] [PubMed:30275816] [PMC:PMC6152484] Related Antibodies: LS-C153337.

OTOF / Otoferlin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.

Human OTOF / Otoferlin Protein (Recombinant GST, N-terminus) (aa1-98) - LS-G61102

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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