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Osteonectin / SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression.
| Gene Name: | secreted protein, acidic, cysteine-rich (osteonectin) |
| Synonyms: | SPARC, Basement-membrane protein 40, BM-40, Cysteine-rich protein, ON, Osteonectin |
| Target Sequences: | NM_003118 NP_003109.1 P09486 |
Publications (3)
1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human)
[Full Text Article]
[PubMed:26982592]
[PMC:PMC4794180]
2
Overexpression of SPARC correlates with poor prognosis in patients with cervical carcinoma and regulates cancer cell epithelial-mesenchymal transition. Shi D, Jiang K, Fu Y, Fang R, Liu XI, Chen J. Oncology letters. 2016 May;11:3251-3258. [Full Text Article]
[PubMed:27123099]
[PMC:PMC4841103]
3
Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells. Liang W, Zhuo X, Tang Z, Wei X, Li B. Molecular and cellular biochemistry. Apr;402:101-10. [Full Text Article]
[PubMed:25563479]
Related Antibodies: LS-C25800.
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(1)
Osteonectin / SPARC Mouse anti-Bovine Monoclonal (ON1-1) Antibody
Bovine, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$567
Osteonectin / SPARC Mouse anti-Human Monoclonal (aa1-304) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$904
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Cancer
Osteonectin / SPARC Mouse anti-Human Monoclonal (2B1) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$440
Osteonectin / SPARC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Osteonectin / SPARC Rabbit anti-Human Polyclonal (Gly53) Antibody
Mouse, Human, Monkey
IP, WB
Unconjugated
100 µl/$688
Osteonectin / SPARC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$826
Osteonectin / SPARC Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr
Unconjugated
500 µg/$1,089
Osteonectin / SPARC Mouse anti-Bovine Monoclonal (ON1-1) Antibody
Bovine, Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$860
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa18-303) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Osteonectin / SPARC Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, WB
Unconjugated
100 µg/$962
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa18-303) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Osteonectin / SPARC Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Zebrafish, Mouse, Horse, Rat, Orangutan, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
Osteonectin / SPARC Guinea pig anti-Rabbit Polyclonal (aa18-273) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa284-303) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Osteonectin / SPARC Mouse anti-Human Monoclonal (Carrier-free) (2B1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Cancer
Fast Shipping
Osteonectin / SPARC Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Osteonectin / SPARC Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
70 µg/$525
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) Antibody
Human
Flo, IHC, WB
Unconjugated
200 µl/$734
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) (Biotin) Antibody
Human
Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Osteonectin / SPARC Rabbit anti-Human Polyclonal (aa224-251) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Fast Shipping
Osteonectin / SPARC Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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