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Osteonectin / SPARC

secreted protein, acidic, cysteine-rich (osteonectin)

SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression.

Gene Name: secreted protein, acidic, cysteine-rich (osteonectin)
Synonyms: SPARC, Basement-membrane protein 40, BM-40, Cysteine-rich protein, ON, Osteonectin
Target Sequences: NM_003118 NP_003109.1 P09486

Publications (2)

1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human) [Full Text Article] [PubMed:26982592] [PMC:PMC4794180]
2
Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells. Liang W, Zhuo X, Tang Z, Wei X, Li B. Molecular and cellular biochemistry. Apr;402:101-10. [Full Text Article] [PubMed:25563479] Related Antibodies: LS-C25800.

Filtered By: None
Target
osteonectin-sparc (88)
Reactivity
Human (64)
Mouse (26)
Rat (21)
Bovine (10)
Chimpanzee (3)
Gibbon (3)
Horse (4)
Monkey (7)
Orangutan (3)
Primate (1)
Rabbit (3)
Sheep (1)
Zebrafish (5)
Application
IHC (60)
IHC-Fr (4)
IHC-P (17)
WB (77)
Flo (16)
ELISA (27)
FLISA (3)
ICC (2)
IF (1)
IP (2)
RIA (1)
Host
rabbit (65)
mouse (18)
goat (1)
guinea pig (3)
rat (1)
Isotype
IgG (44)
IgG1 (15)
IgG1,k (3)
IgG2b (1)
Clonality
monoclonal mc (19)
polyclonal pc (69)
Clone
1B2 (1)
1D6 (1)
2B1 (1)
5031 (1)
BSB 93 (2)
LM2 (1)
ON1-1 (2)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (8)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (5)
Ready-to-Use (1)
Unconjugated (49)
Epitope
aa224-251 (9)
aa18-301 (8)
aa18-302 (8)
aa18-303 (8)
C-Terminus (4)
aa18-273 (3)
aa1-304 (2)
Gly53 (1)
Internal (1)
aa1-120 (1)
aa141-190 (1)
aa179-197 (1)
aa268-303 (1)
aa272-286 (1)
aa284-303 (1)
aa46-63 (1)
aa52-56 (1)
Publications
No (87)
Yes (1)
Showing 1-25 out of 88 results
Osteonectin / SPARC Antibody (C-Terminus) IHC-plus™ LS-B11553
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human Osteonectin / SPARC
Zebrafish, Horse, Mouse, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody (aa1-304, Biotin) LS-C280453

Mouse Monoclonal (IgG1,k) to Human Osteonectin / SPARC
Human
WB
Biotin Conjugated
Osteonectin / SPARC Antibody (clone 5031) LS-C25800

Mouse Monoclonal [clone 5031] (IgG1) to Human Osteonectin / SPARC
Bovine, Rat, Human
ELISA IHC RIA WB
Unconjugated
Osteonectin / SPARC Antibody (Gly53) LS-C191122

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Mouse, Human, Monkey
IF IP WB
Unconjugated
Osteonectin / SPARC Antibody (clone ON1-1) LS-C83590

Mouse Monoclonal [clone ON1-1] (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
IHC IHC-Fr IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody LS-C25802

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA IHC IHC-P
Unconjugated
Osteonectin / SPARC Antibody (aa224-251, Biotin) LS-C280447

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
Flo IHC WB
Biotin Conjugated
Osteonectin / SPARC Antibody (aa224-251, FITC) LS-C280448

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA Flo IHC WB
FITC Conjugated
Osteonectin / SPARC Antibody (aa224-251, APC) LS-C280445

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA Flo IHC WB
APC Conjugated
Osteonectin / SPARC Antibody (aa224-251, AP) LS-C280446

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA Flo IHC WB
AP Conjugated
Osteonectin / SPARC Antibody (aa224-251, PE) LS-C280450

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA Flo IHC WB
PE Conjugated
Osteonectin / SPARC Antibody (aa224-251, Azide-free, HRP) LS-C280449

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Human
ELISA Flo IHC WB
HRP Conjugated, Azide-free
Osteonectin / SPARC Antibody LS-C124320

Rat Monoclonal (IgG2b) to Mouse Osteonectin / SPARC
Mouse
ELISA Flo IHC IHC-Fr
Unconjugated
Osteonectin / SPARC Antibody (clone ON1-1) LS-C25804

Mouse Monoclonal [clone ON1-1] (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
ELISA Flo IHC WB
Unconjugated
Osteonectin / SPARC Antibody (Biotin) LS-C528386

Mouse Monoclonal (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
ELISA Flo IHC WB
Biotin Conjugated
Osteonectin / SPARC Antibody (FITC) LS-C538342

Mouse Monoclonal (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
FLISA Flo IHC WB
FITC Conjugated
Osteonectin / SPARC Antibody (APC) LS-C518486

Mouse Monoclonal (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
FLISA Flo IHC WB
APC Conjugated
Osteonectin / SPARC Antibody (PE) LS-C656507

Mouse Monoclonal (IgG1) to Bovine Osteonectin / SPARC
Bovine, Human
FLISA Flo IHC WB
PE Conjugated
Osteonectin / SPARC Antibody LS-C131158

Goat Polyclonal (IgG) to Mouse Osteonectin / SPARC
Mouse
ELISA Flo WB
Unconjugated
Osteonectin / SPARC Antibody (clone 2B1) IHC-plus™ LS-B13205
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Mouse Monoclonal [clone 2B1] (IgG1) to Human Osteonectin / SPARC
Human
IHC IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody (aa224-251) LS-C161424
Formalin-fixed and paraffin-embedded human skin tissue reacted with SPARC Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of SPARC Antibody in Y79 cell line lysates (35 ug/lane). SPARC (arrow) was detected using the purified antibody.

Rabbit Polyclonal to Human Osteonectin / SPARC
Human
Flo IHC IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody (clone LM2) LS-C140650

Mouse Monoclonal [clone LM2] (IgG1) to Human Osteonectin / SPARC
Human
Flo IHC IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody (aa141-190) LS-C387280
Immunohistochemistry of SPARC antibody
Western blot of SPARC antibody

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Mouse, Rat, Human
ELISA IHC IHC-P WB
Unconjugated
Osteonectin / SPARC Antibody LS-C401048
Immunohistochemistry of Human liver cancer using SPARC Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of Human thyroid cancer using SPARC Polyclonal Antibody at dilution of 1:25.

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Osteonectin / SPARC Antibody LS-C331587
Immunohistochemistry of paraffin-embedded rat kidney using SPARC antibody at dilution of 1:100 (200x lens).
Immunohistochemistry of paraffin-embedded rat Intestine.

Rabbit Polyclonal (IgG) to Human Osteonectin / SPARC
Mouse, Rat, Human
IHC WB
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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